PUBLICATIONS

Chen, J.; Chao, D.; Tran, U.; Billingsley, K.* “Design, Synthesis, and Assessment of Tricarboxylic Acid Cycle Probes” Synthesis 2024.

Tran, U.; Billingsley, K.* “Biological Evaluation of Indolactams for In Vitro Bryostatin 1-Like Activity” Bioorg. Med. Chem. Lett. 2024, 97, 129570.

Chen, J.; Singh, T. K.; Al Nemri, S.; Zaidi, M.; Billingsley, K.;* Park, J. M.* “Hyperpolarized [1-13C]Acetyl-L-Carnitine Probes Tricarboxylic Acid Cycle Activity In Vivo” ACS Sensors 2023, 8, 2927-2932.

Mendoza, M.; Tran, U.; Zhang, G. C.; Leister, J.; To, K.; Malepeai-Tofaeono, T.; Ondrus, A. E.;* Billingsley, K.* "Indolactam Dipeptides as Nanomolar Gli Inhibitors" ACS Med. Chem. Lett. 2022, 13, 1036–1042.

Chen, J.; LaGue, E.; Mendoza, M.; Li, J.; Yang, C.; Hackett, E. P.; Alger, J. R.; DeBerardinis, R. J.; Corbin, I. R.; Billingsley, K. L.*; Park, J. M.* “Profiling Carbohydrate Metabolism in Liver and Hepatocellular Carcinoma with [13C]-Glycerate Probes.” Analysis & Sensing 2021, 1, 196-202. ​

Hackett, E.; Shah, B. R.; Cheng, B.; LaGue, E.; Vemireddy, V.; Mendoza, M.; Bing, C.; Bachoo, R. M.; Billingsley, K.; Chopra, R.; Park, J. M. “Probing Cerebral Metabolism with Hyperpolarized 13C Imaging after Opening the Blood-Brain Barrier with Focused Ultrasound.” ACS Chem. Neuorosci. 2021, 12, 2820-2828. ​

Leister, J.; Chao, D.; Billingsley, K.* “Palladium-Catalyzed Prenylation of (Hetero)Aryl Boronic Acids.” Tetrahedron Lett. 2021, 66, 152800.

Tran, U.; Zhang, G.; Eom, R.; Billingsley, K.*; Ondrus, A.* “Small Molecule Intervention in a Protein Kinase C - Gli Transcription Factor Axis.” ACS Chem. Bio. 2020, 15, 1321-1327. ​

Mendoza, M.; Eom, R.; Salas, C.; Haynes-Smith, J.; Billingsley, K.* “The Synthesis and Biological Evaluation of Indolactam Alkaloids.” Synthesis 2019, 51, 4443-4451. ​

Mendoza, M.; Rao, N.; Tran, U.; Castaneda, C.; Billingsley, K.* “Total Synthesis of (-)-Indolactam I.” Tetrahedron 2019, 75, 4337-4342. ​

Park, J. M.;* Wu, M.; Datta, K.; Liu, S.-C.; Castillo, A.; Lough, H.; Spielman, D. M.;* Billingsley, K.* “Hyperpolarized Sodium [1-13C]-Glycerate as a Probe for Assessing Glycolysis In Vivo.” J. Am. Chem. Soc. 2017, 139, 6629-6634. ​

Haynes-Smith, J.; Diaz, I.; Billingsley, K.* “Modular Total Synthesis of Protein Kinase C Activator (-)-Indolactam V.” Org. Lett. 2016, 18, 2008-2011.

Thomas, C.; Wu, M.; Billingsley, K.* “An Amination-Oxidation Strategy for the Synthesis of Monoarylamines.” J. Org. Chem. 2016, 81, 330-335.

Josan, S.; Billingsley, K.; Orduna, J.; Park, J. M.; Luong, R.; Yu, L.; Hurd, R.; Pfefferbaum, A.; Spielman, D.; Mayer, D. “Assessing Inflammatory Liver Injury in an Acute CCl4 Model using Dynamic 3D Metabolic Imaging of Hyperpolarized [1-13C]-Pyruvate.” NMR Biomed. 2015, 28, 1671-1677.

Loy, B. A.; Lesser, A. B.; Staveness, D.; Billingsley, K.; Cegelski, L.; Wender, P. A. “Toward a Biorelevant Structure of Protein Kinase C Bound Allosteric Modulators: Design, Synthesis, and Evaluation of Labeled Bryostatin Analogs for Analysis with Solid-State REDOR NMR Spectroscopy.” J. Am. Chem. Soc. 2015, 137, 3678-3685.

Billingsley, K.;* Josan, S.; Park, J. M.; Tee, S. S.; Spielman-Sun, E.; Hurd, R.; Mayer, D.; Spielman, D. “Hyperpolarized [1,4-13C]-Diethylsuccinate: A Potential DNP Substrate for In Vivo Metabolic Imaging.” NMR Biomed. 2014, 27, 356-362.

Billingsley, K.;* Park, J. M.; Josan, S.; Hurd, R.; Mayer, D.; Spielman-Sun, E.; Nishimura, D.; Brooks, J. D.; Spielman, D. “The Feasibility of Assessing Branched-Chain Amino Acid Metabolism in Cellular Models of Prostate Cancer with Hyperpolarized [1-13C]-Ketoisocaproate.” Magn. Reson. Imaging 2014, 32, 791-795.

Düfert, M. A.; Billingsley, K.; Buchwald, S. L. “Suzuki-Miyaura Cross-Coupling of Unprotected, Nitrogen-Rich Heterocycles: Substrate Scope and Mechanistic Investigation.” J. Am. Chem. Soc. 2013, 135, 12877-12885.

Wender, P. A.; Billingsley, K. “Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues.” Synthesis 2013, 45, 1815-1824. ​

Josan, S.; Hurd, R.; Billingsley, K.; Senadheera. L; Park, J.; Yen, Y.-F.; Pfefferbaum, A.; Spielman, D.; Mayer, D. “Effects of Isoflurane Anesthesia on Hyperpolarized 13C Metabolic Measurements in Rat Brain.” Magn. Reson. Med. 2013, 70, 1117-1124.

Balaconis, M. K.; Billingsley, K.; Dubach, M.; Cash, K. J.; Clark, H. A. “The Design and Development of Fluorescent Nano-Optodes for In Vivo Glucose Monitoring.” J. Diabetes Sci. Technol. 2011, 5, 1650-1657.

Billingsley, K.; Balaconis, M. K.; Dubach, J. M.; Zhang, N.; Lim, E.; Francis, K. P.; Clark, H. A. “Fluorescent Nano-Optodes for Glucose Detection.” Anal. Chem. 2010, 82, 3707-3013. ​

Billingsley, K.; Buchwald, S. L. “A General and Efficient Method for the Suzuki-Miyaura Coupling of 2-Pyridyl Nucleophiles.” Angew. Chem. Int. Ed. 2008, 47, 4695-4698. ​

Billingsley, K.; Buchwald, S. L. “An Improved System for the Palladium-Catalyzed Borylation of Aryl Halides with Pinacol Borane.” J. Org. Chem. 2008, 73, 5589-5591.

Billingsley, K.; Barder, T. E.; Buchwald, S. L. “Palladium-Catalyzed Borylation of Aryl Chlorides: Scope, Applications, and Computational Studies.” Angew. Chem. Int. Ed. 2007, 46, 5359-5363.

Billingsley, K.; Buchwald, S. L. “Highly Efficient Monophosphine-Based Catalyst for the Palladium-Catalyzed Suzuki-Miyaura Reaction of Heteroaryl Halides and Heteroaryl Boronic Acids and Esters.” J. Am. Chem. Soc. 2007, 129, 3358-3366.

Billingsley, K.; Anderson, K. W.; Buchwald, S. L. “A Highly Active Catalyst for Suzuki-Miyaura Cross-Coupling Reactions of Heteroaryl Compounds.” Angew. Chem. Int. Ed. 2006, 45, 3484-3488.

Brizius, G.; Billingsley, K.; Smith, M. D.; Bunz, U. H. F. “Conformational and Electronic Engineering of Twisted Diphenylacetylenes.” Org. Lett. 2003, 5, 3951-3954.